Natural progesterone cream is a natural hormonal product.

The hormone progesterone has countless functions in the body: regulating periods and pregnancy in women, sperm production in men, building bones, regulating blood sugar and body fat stores, developing intelligence, brain activity, sleep regulation, immune function, kidney function and many more.

Natural progesterone therapy has been practiced for over  50 years in the treatment of a wide variety of symptoms and diseases that are hormonally related. During this time no adverse side effects have been reported.*

Recommendations on how to use Natural Progesterone Cream:

To use apply 1/4 teaspoon (pea-sized amount) externally by rubbing cream onto unbroken skin (it is a good idea to vary the area to improve absorption and use thin skin e.g. inside of wrist, over collarbone) or apply vaginally (believed to improve absorption). Do this morning and night.

Menstruating women with regular cycles (otherwise follow calendar month as below):

  • Stop using the cream when your period begins and re-start when it has stopped.
  • If you have any new mid-cycle bleeding consult your GP.

Post-menopausal (periods absent), post hysterectomy or while pregnant/ breast-feeding:

  • Count the first day of the calendar month as Day 1. Apply cream as directed above but stop on Day 27 and resume the following month on Day 1.
  • If you have any new bleeding over 12 months after periods have stopped, consult your GP.


  • Apply 1/4 teaspoon of the cream onto unbroken skin once daily. Stop on Day 27 of the calendar month and resume on the 1st of the following month.

* Many people are confused between natural progesterone and the synthetic progestins, medications which are also commonly called Progesterone. They have many side effects and are not the same as natural progesterone cream.

jlee_150Dr John Lee M.D. pioneered the use of natural progesterone cream and wrote several excellent books explaining the role of progesterone in menopause, breast cancer, men and the menstrual cycle:

  • Dr John Lee & Virginia Hopkins (2005). What Your Doctor May Not Tell You About Menopause.
  • Dr John Lee, David Zava, Virginia Hopkins (2005). What Your Doctor May Not Tell You About Breast Cancer: How Hormone Balance Can Save Your Life. 
  • Dr John Lee & Virginia Hopkins (2006). Dr John Lee’s Hormone Balance Made Simple: The Essential How-to Guide to Symptoms, Dosage, Timing and More.
  • Dr John Lee (2003). Hormone Balance for Men. Available to download here

You can listen to one of his lectures on progesterone for free here

“Ample medical research regarding progesterone was carried on in the 1940’s through the 1960’s, and amply reported in mainline, recognized medical literature. Since the early 1970’s, however, medical research has become much more expensive and the grants subsidizing progesterone research, (or any unpatentable medicine or treatment technique), have dried up and been blown away by the contemporary trade winds of synthetic drugs, particularly the progestins. The potential market for patentable progestins is vast — contraceptive pills, irregular menses, osteoporosis…. — literally every woman through the age of puberty on is a target for a sale. Do you think the prevailing powers wish to see this lucrative market left to an over-the-counter natural product not in the hands of physician prescribers and not controlled by the pharmaceutical industry? 

Thus, when he (the physician) hears of the use of natural progesterone, he wonders why none of his associates know about it. If it is not commonly known, ‘it must in some way be false and/or unapproved.’ Having given lectures on the role and medical uses of natural progesterone, I have observed numerous instances wherein perfectly fine physicians will inquire about obtaining the product for use by their wives or mother-in-law but not for their patients. What can account for such behavior by professionals? I suspect that it is fear of alienation from the flock that is paramount in their minds….

If progestins were the equivalent of natural progesterone in effect and safety, the argument would be moot. But progestins are not the equivalent of natural progesterone and never will be…….”

Dr John R. Lee, 1997

Published information on Natural Progesterone cream:

  • Chang, K.J. et al (1995). Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo. Fertil Steril63, 785-791
  • Cowan, L. et al (1985). Breast Cancer incidence in women with Progesterone deficiency. Am. J. Epidemiol. 114 (2), 209-217
  • Fitzpatrick, L. et al (2000). Comparison of regimens containing oral micronized progesterone or medroxyprogesterone acetate on quality of life in postmenopausal women: A cross-sectional survey. Journal of Women’s Health Gender-based Medicine(4), 381-7 (The side effects of the synthetics include bloating, nausea and depression were eliminated by using natural progesterone. In fact unexpected improvement in the feeling of well-being was observed when natural progesterone was used)
  • Formby, B. and Wiley, T.S. (1998). Progesterone inhibits growth and induces apoptosis in breast cancer cells: inversive effects on Bcl-2 and p53. Ann Clin Lab Sci28, 360-69
  • Hermsmeyer, R.K. et al (2004). Prevention of coronary hyper-reactivity in pre-arthrogenic menopausal rhesus monkeys by transdermal progesterone. Arterioscler Thromb Vasc Biol24, 955-61
  • Lee, J. R. (1990). Osteoporosis Reversal. The Role of Progesterone. Int Clin Nutr Rev10 (3), 384-91
  • Lee, J. R. (1995). Natural Progesterone: The Multiple Roles of a Remarkable Hormone. BLL Publishing: California
  • Lee, W.S. et al (1997). Progesterone inhibits arterial smooth muscle proliferation. Nat Med3, 1005-8
  • Leonetti, H.B. et al (1999). Transdermal Progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstet Gynecol 94 (2), 225-8
  • Murray, J. Natural Progesterone: What Role in Women’s Healthcare?. Available from: http://womeninbalance.org/choices-in-therapy/hormone-treatment-options/ (respected US Doctor M.D. and former head of the American Academy of Family Physicians argues there have been no studies to date of any harm to women from Natural Progesterone)
  • The writing group for the PEPI Trial (1995). Effects of Estrogen/ Progestin regimens on heart disease risk factors in postmenopausal women. The PostmenopausalEstogen/ Progestin Interventions PEPI trial. JAMA. 273 (3), 199-208 Trials show Natural Progesterone more effective than synthetic
  • Ryan, N. and Rosner, A. (2001). Quality of life and costs associated with micronized progesterone and medroxyprogesterone acetate in hormone replacement therapy for nonhysterectomized, postmenopausal women. Clin Ther23, 1099-1115
  • Rylance, P.B. et al (1985). Natural Progesterone ad anti-hypertensive action. Br Med J (Clin Res Ed)290 (6461), 13-14
  • Schumacher, M. et al (2004). Local synthesis and dual actions of progesteone in the nervous system: Neuroprotection and myelination.  Growth Horm IGF Res. 14, S18-33
  • Stephenson, K. et al (2004). Progesterone does not increase thrombotic and inflammatory factors in postmenopausal women. Blood104 (16).
  • Wright, J.V. & Morgenthaler, J. (1997). Natural Progesterone. Smart Publications: California